Coffee Consumption Shown to be Protective of Human DNA
Title: Coffee consumption rapidly reduces background DNA strand breaks in healthy humans: Results of a short term repeated uptake intervention study
Author: Bakarudze et al
Journal: Molecular Nutrition & Food Research
Objective: The authors sought to assess whether short-term coffee consumption correlates with reduced DNA background damage in healthy volunteers.
Coffee has numerous benefits which I have reported on previously. A few of the big ones include:
- Increased alertness and decreased fatigue (obviously!)
- Treatment for headaches
- Reduced risk of heart disease with moderate consumption
- May help with diabetes
- Reduction in risk of alzheimer’s, parkinson’s disease
- Improved athletic performance
- Overall decrease in mortality (risk of death)
But why does it have all of these effects is not well understood. Some of the proposed molecules that may be beneficial include:
- chlorogenic acids
The authors of this study had previously reported that 4 weeks of coffee consumption rich in chlorogenic acid reduced dna strand breaks and increased glutathione levels. This finding has been recreated in other studies.
What they wanted to know in this publication was whether that protective benefit in DNA breaks was measurable in hours and not weeks.
14 healthy male subjects ingested coffee in 200 ml aliquots every 2 hours up to a total volume of 800 ml over 8 hours.
They took blood samples at baseline and then right before coffee consumption every 2 hours.
They then measured DNA integrity by comet assay.
The results show a significant reduction of background DNA strand breaks as early as 2 hours after the first coffee intake. (p<0.05).
Continued coffee intake was associated with further decrements in background DNA damage within the 8h intervention.
There was a decrease in background DNA damage as early as 2 hours after coffee intake.
The implications of this are important.
It suggests a way in which coffee is protective against certain chronic diseases.
It also allows for more basic science investigations to determine exactly which molecules are specifically responsible and use this molecule to potentially treat chronic diseases.
Bakuradze, T., Lang, R., & Hofmann, T. (2015). Coffee consumption rapidly reduces background DNA strand breaks in healthy humans: Results of a short-term repeated uptake intervention study. Molecular Nutrition & Food Research,60(3), 682-686. doi:10.1002/mnfr.201500668